![10-phenyl-N-(3-pyridinylmethyl)-9-azatetracyclo[10.2.1.0~2,11~.0~3,8~]pentadeca-3,5,7-triene-5-carboxamide](https://img.chemicalbook.com/CAS/20180711/GIF/1005095-04-4.gif)
LN-145532
10-phenyl-N-(3-pyridinylmethyl)-9-azatetracyclo[10.2.1.0~2,11~.0~3,8~]pentadeca-3,5,7-triene-5-carboxamide , NLT 98% , 1005095-04-4
Update time: 2023-04-23
PRODUCT Properties
| Boiling point: | 622.1±55.0 °C(Predicted) |
| Density | 1.199±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 50mg/mL |
| form | solid |
| pka | 13.90±0.40(Predicted) |
| color | white |
Description and Uses
A cell permeable methanophenanthridine derivative that acts a selective inhibitor of SIRT2 (IC50 = 3.8 µM) and exhibits ~30 fold greater selectivity over SIRT1 (IC50 >100 µM) and SIRT3. Blocks SIRT2-induced p53 deacetylation and thereby elevates p53 levels and causes increased expression of CDKN1A, PUMA, and NOXA in non-small cell lung cancer (NSCLC) A549 cells. Also shown to reduce NSCLC cell viability by 50% (~20 µM) and inhibit their proliferation. Sensitizes A549 cancer cell line to etoposide (~1 µM) induced DNA damage in a p53-dependent manner.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Safety
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |