LN-527333
Loperamide , 99 , 53179-11-6
CAS NO.：53179-11-6
Empirical Formula: C29H33ClN2O2
Molecular Weight: 477.04
MDL number: MFCD00600388
Update time: 2023-04-23
PRODUCT Properties
| Boiling point: | 647.2±55.0 °C(Predicted) |
| Density | 1.187±0.06 g/cm3(Predicted) |
| pka | pKa 8.66(H2O) (Uncertain) |
| BCS Class | 4 |
| InChI | InChI=1S/C29H33ClN2O2/c1-31(2)27(33)29(24-9-5-3-6-10-24,25-11-7-4-8-12-25)19-22-32-20-17-28(34,18-21-32)23-13-15-26(30)16-14-23/h3-16,34H,17-22H2,1-2H3 |
| InChIKey | RDOIQAHITMMDAJ-UHFFFAOYSA-N |
| SMILES | C(C(=O)N(C)C)(CCN1CCC(O)(C2=CC=C(Cl)C=C2)CC1)(C1=CC=CC=C1)C1C=CC=CC=1 |
| LogP | 2.641 at 25℃ and pH6.95 |
| CAS DataBase Reference | 53179-11-6(CAS DataBase Reference) |
| NIST Chemistry Reference | Loperamide(53179-11-6) |
Description and Uses
Loperamide is presently used more often as an antidiarrheal drug than as an analgesic, and it is also included in the list of over-the-counter drugs because of its insignificant action on the CNS. It reduces intestinal smooth muscle tone and motility as a result of binding to intestinal opiate receptors. It is used for symptomatic treatment of severe and chronic diarrhea of various origins. The most popular synonym for loperamide is imodium.
Safety
| Symbol(GHS) |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501 |
| Hazardous Substances Data | 53179-11-6(Hazardous Substances Data) |
