LN-679334
19-Epi FK-506 , 0.95 , 144490-63-1
Update time: 2023-04-23
PRODUCT Properties
| Boiling point: | 871.7±75.0 °C(Predicted) |
| Density | 1.19±0.1 g/cm3(Predicted) |
| pka | 9.97±0.70(Predicted) |
| InChIKey | QJJXYPPXXYFBGM-ZADLGOIHNA-N |
Description and Uses
19-Epi FK-506 is an impurity in the synthesis of FK-506 [Tacrolimus] (F370000), an immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release.
