LN-833231
Ethaselen , 217798-39-5
Update time: 2023-04-23
PRODUCT Properties
| Boiling point: | 580.5±60.0 °C(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : 12.5 mg/mL (29.61 mM; ultrasonic and warming and heat to 60°C) |
| form | Solid |
| pka | -1.86±0.20(Predicted) |
| color | Light yellow to yellow |
Description and Uses
Ethaselen (BBSKE) is an orally active, selective thioredoxin reductase (TrxR) inhibitor with IC50s of 0.5 and 0.35 μM for the wild-type human TrxR1 and rat TrxR1, respectively. Ethaselen specifically binds to the unique selenocysteine-cysteine redox pair in the C-terminal active site of mammalian TrxR1. Ethaselen, an organoselenium compound, is a potent antitumor candidate that exerts potent inhibition on non-small cell lung cancer (NSCLC) by targeting TrxR[1][2].