LN-889916
RP107 , 95% , 496864-16-5
Synonym(s):
Aloisine A - CAS 496864-16-5 - Calbiochem;RP107, 7- n-Butyl-6-(4-hydroxyphenyl)[5H]pyrrolo[2,3-b]pyrazine
Update time: 2023-04-23
PRODUCT Properties
| Melting point: | 281-283°C |
| Density | 1.227 |
| storage temp. | Keep in dark place,Sealed in dry,2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Yellow solid |
| pka | 9.67±0.15(Predicted) |
| color | Light Orangish Yellow |
| InChI | 1S/C16H17N3O/c1-2-3-4-13-14(11-5-7-12(20)8-6-11)19-16-15(13)17-9-10-18-16/h5-10,20H,2-4H2,1H3,(H,18,19) |
| InChIKey | PRIGRJPRGZCFAS-UHFFFAOYSA-N |
| SMILES | [nH]1c2nccnc2c(c1c3ccc(cc3)O)CCCC |
Description and Uses
A cell-permeable pyrrolo-pyrazine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin dependent kinases (Cdks: IC50 =150nM, 120 nM, 400 nM and 200 nM for Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p25,
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P305+P351+P338 |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36/37 |
| WGK Germany | WGK 1 |
| Storage Class | 11 - Combustible Solids |
