LN-954132
4-Quinazolinamine, N-cyclohexyl-2-cyclopropyl- , 98% HPLC , 1002801-51-5
Update time: 2023-04-23
PRODUCT Properties
| Boiling point: | 382.2±30.0 °C(Predicted) |
| Density | 1?+-.0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| pka | 6.96±0.50(Predicted) |
| form | Solid |
| color | White to off-white |
| InChIKey | ZQMGQZOHIDOPCQ-UHFFFAOYSA-N |
| SMILES | C1(N=C(C2CC2)N=C3NC4CCCCC4)=C3C=CC=C1 |
Description and Uses
TH10785 is a DNA glycosylase 1 (OGG1) activator, TH10785 can interact with the phenylalanine-319 and glycine-42 amino acids of OGG1 and increase the enzyme activity, generates β, δ-lyase enzymatic function. TH10785 can control the catalytic activity mediated by a nitrogen base within its molecular structure. TH10785 can be used for the research of various diseases and aging connected with DNA oxidative lesions[1].
Safety
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |