3-nitro-N-(4-phenoxyphenyl)-benzamide , 98% HPLC , 316146-57-3
PRODUCT Properties
| Boiling point: | 430.9±30.0 °C(Predicted) |
| Density | 1.333±0.06 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | DMSO: >20mg/mL |
| pka | 11.76±0.70(Predicted) |
| form | Solid |
| color | off-white to light tan |
| InChI | InChI=1S/C19H14N2O4/c22-19(14-5-4-6-16(13-14)21(23)24)20-15-9-11-18(12-10-15)25-17-7-2-1-3-8-17/h1-13H,(H,20,22) |
| InChIKey | GDWKBKTVROCPNZ-UHFFFAOYSA-N |
| SMILES | C(NC1=CC=C(OC2=CC=CC=C2)C=C1)(=O)C1=CC=CC([N+]([O-])=O)=C1 |
Description and Uses
ICA-105574 is a potent and efficacious hERG channel activator. The primary mechanism by which ICA-105574 potentiates hERG channel activity is by removing hERG channel inactivation. ICA-105574 steeply potentiates current amplitudes more than 10-fold with an EC50 value of 0.5 +/- 0.1 μM and a Hill slope (n(H)) of 3.3 +/- 0.2. ICA-105574 shifts the voltage dependence of Ptype inactivation to a very positive direction and removes the hERG channel from inactivation at physiological membrane potentials[1].
ICA-105574 is a potent and efficacious hERG channel activator. The primary mechanism by which ICA-105574 potentiates hERG channel activity is by removing hERG channel inactivation. ICA-105574 steeply potentiates current amplitudes more than 10-fold with an EC50 value of 0.5 +/- 0.1 μM and a Hill slope (n(H)) of 3.3 +/- 0.2[1].
Safety
| Symbol(GHS) |   GHS07,GHS09 |
| Signal word | Warning |
| Hazard statements | H317-H319-H400 |
| Precautionary statements | P273-P280-P305+P351+P338 |
| Hazard Codes | Xi,N |
| Risk Statements | 36-43-50/53 |
| Safety Statements | 26-36/37-60-61 |
| RIDADR | UN 3077 9 / PGIII |