LN-981332
TED-347 , 98% HPLC , 2378626-29-8
CAS NO.：2378626-29-8
Empirical Formula: C15H11ClF3NO
Molecular Weight: 313.7
MDL number: MFCD32689460
Update time: 2023-04-23
PRODUCT Properties
| Boiling point: | 378.0±42.0 °C(Predicted) |
| Density | 1.352±0.06 g/cm3(Predicted) |
| pka | -2.67±0.50(Predicted) |
| form | Solid |
| color | Light yellow to green yellow |
| InChI | InChI=1S/C15H11ClF3NO/c16-9-14(21)12-6-1-2-7-13(12)20-11-5-3-4-10(8-11)15(17,18)19/h1-8,20H,9H2 |
| InChIKey | JPVDFGYNLUBCSD-UHFFFAOYSA-N |
| SMILES | C(=O)(C1=CC=CC=C1NC1=CC=CC(C(F)(F)F)=C1)CCl |
Description and Uses
TED-347 is a potent, irreversible, covalent and allosteric inhibitor at YAP-TEAD protein-protein interaction with an EC50 of 5.9 μM for TEAD4?Yap1 protein-protein interaction. TED-347 specifically and covalently bonds with Cys-367 within the central pocket of TEAD4 with a Ki of 10.3 μM. TED-347 blocks TEAD transcriptional activity and has antitumor activity[1].
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P337+P313-P305+P351+P338-P302+P352-P332+P313-P362 |