LN-995132
SY-5609 , 98% HPLC , 2417302-07-7
CAS NO.：2417302-07-7
Empirical Formula: C23H26F3N6OP
Molecular Weight: 490.46
MDL number: MFCD34471213
Update time: 2023-04-23
PRODUCT Properties
| Boiling point: | 751.4±70.0 °C(Predicted) |
| Density | 1.36±0.1 g/cm3(Predicted) |
| storage temp. | 4°C, stored under nitrogen |
| solubility | DMSO : 40 mg/mL (81.56 mM; Need ultrasonic) |
| pka | 11.05±0.30(Predicted) |
| form | Solid |
| color | White to light yellow |
| InChIKey | JDJOUBVVSQDIRC-AWEZNQCLSA-N |
| SMILES | N1C2=C(C=CC(C#N)=C2P(C)(C)=O)C(C2C(C(F)(F)F)=CN=C(N[C@H]3CCC(C)(C)NC3)N=2)=C1 |
Description and Uses
SY-5609 (CDK7-IN-3) is an orally active, highly selective, noncovalent CDK7 inhibitor with a KD of 0.065 nM. SY-5609 shows poor inhibition on CDK2 (Ki=2600 nM), CDK9 (Ki=960 nM), CDK12 (Ki=870 nM). SY-5609 induces apoptosis in tumor cells and has antitumor activity[1][2].