98% , 1431697-81-2

CAS NO.：1431697-81-2

Empirical Formula: C21H16ClF3N4O3

Molecular Weight: 464.82

MDL number:

PRODUCT Properties

• Boiling point: 520.0±50.0 °C(Predicted)
• Density: 1.454±0.06 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: DMSO (Slightly), Methanol (Slightly)
• form: Solid
• pka: 12.84±0.70(Predicted)
• color: White to Pale Yellow
• Major Application: pharmaceutical
• InChI: 1S/C21H16ClF3N4O3/c1-26-19(30)17-11-14(9-10-27-17)32-13-7-5-12(6-8-13)28-20(31)29-16-4-2-3-15(18(16)22)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)
• InChIKey: JWAKXXCHFJSKRN-UHFFFAOYSA-N
• SMILES: FC(F)(F)c1c(c(ccc1)NC(=O)Nc2ccc(cc2)Oc3cc(ncc3)C(=O)NC)Cl

Description and Uses

4-Deschloro-2-chloro-Sorafenib is a derivative of Sorafenib (S676850), a multiple kinase inhibitor targeting both RAF kinase and receptor tyrosine kinases that promote angiogensis. Antineoplastic.

Safety

• Symbol(GHS): GHS08,GHS09
• Signal word: Danger
• Hazard statements: H360FD-H362-H372-H410
• Precautionary statements: P202-P260-P263-P264-P273-P308+P313
• WGK Germany: WGK 3
• HS Code: 2933399090
• Storage Class: 6.1C - Combustible acute toxic Cat.3; toxic compounds or compounds which causing chronic effects
• Hazard Classifications: Aquatic Acute 1; Aquatic Chronic 1; Lact.; Repr. 1B; STOT RE 1