LN5750348
97% , 57444-62-9
| Pack Size | Price | Stock | Quantity |
| 1mg | RMB1062.40 | In Stock |
|
| 5mg | RMB3870.40 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Boiling point: | 768.7±60.0 °C(Predicted) |
| Density | 1.35±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO to 100mM and to 50mM in ethanol |
| form | Solid |
| pka | 9.85±0.20(Predicted) |
| color | White to off-white |
| biological source | Euphorbia poisonii |
| BRN | 5371150 |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| InChIKey | DSDNAKHZNJAGHN-MXTYGGKSSA-N |
| SMILES | C1(CC(OCC2C[C@@]3(O)[C@]([H])([C@]45O[C@]6(CC7=CC=CC=C7)O[C@]([H])([C@]4([H])C=2)[C@](C(C)=C)(C[C@H]5C)O6)C=C(C)C3=O)=O)=CC=C(O)C(OC)=C1 |
Description and Uses
Resiniferatoxin (57444-62-9) is an ultrapotent TRPV1 activator (Ki=43 pM).1 Resiniferatoxin is 100-10,000 fold more potent than capsaicin for most responses yet displays a spectrum of activity distinct from capsaicin.2 A potent sensory neuron excitotoxin.3 Induces a long lasting analgesia in a rodent model of burn pain.4 SEVERE IRRITANT – HANDLE WITH CARE
Resiniferatoxin has been used as an agonist to transient receptor potential vanilloid 2 (TRPV2):
- for complex preparation for cryo-electron microscopy structural studies
- to test its effect towards immune responses to?P.?aeruginosa in sensory neurons associated with the cornea
- to study its effects in the denervation of the peripheral sensory nerves in psoriatic mice
Safety
| Symbol(GHS) |   GHS05,GHS06 |
| Signal word | Danger |
| Hazard statements | H315-H319-H335-H301-H314 |
| Precautionary statements | P261-P280a-P301+P310a-P405-P501a-P280-P305+P351+P338-P310 |
| Hazard Codes | T |
| Risk Statements | 25-35 |
| Safety Statements | 26-36/37/39-45 |
| RIDADR | UN 2928 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | CY1633700 |
| F | 10-23 |
| HazardClass | 6.1(a) |
| PackingGroup | II |
| HS Code | 29329990 |
