PenitremA , 95% , 12627-35-9
Synonym(s):
Tremortin A
CAS NO.：12627-35-9
Empirical Formula: C37H44ClNO6
Molecular Weight: 634.2
MDL number: MFCD12547934
EINECS: 634-132-0
| Pack Size | Price | Stock | Quantity |
| 5MG | RMB1707.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 238°C |
| Density | 1.0241 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO (up to 6 mg/ml) |
| form | White solid. |
| pka | 13.22±0.70(Predicted) |
| color | Amorphous solid |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| InChIKey | JDUWHZOLEDOQSR-JKPSMKLGSA-N |
Description and Uses
Penitrem A (12627-35-9) is a fungal mycotoxin that acts as a selective, irreversible blocker of the smooth muscle high conductance Ca2+-activated K+?(BK, KCa1.1) channel (100% block at 10 nM).1?Displays brain neurotoxicity in rats along with dose-dependent convulsions and death.2?An important tool for studying the role of BK channels in vascular function which is effective in cellular, tissue and?in vivo?experiments.3?Inhibits BK channels in inside-out and cell-attached patches, whereas iberiotoxin (considered the gold standard BK channel blocker) does not.3?May be used to partially ablate Purkinje cells in immature rat cerebellum providing a model for neural stem cell transplantation studies.4
Penitrem A has been used as Ca2+-Activated K+ (BK) channel blocker to study its effect on BK current in bag cell neurons.
Safety
| Symbol(GHS) |  GHS06 |
| Signal word | Danger |
| Hazard statements | H300 |
| Precautionary statements | P301+P330+P331+P310 |
| PPE | Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges |
| Hazard Codes | T+,T |
| Risk Statements | 26/27/28 |
| Safety Statements | 36/37/39-45 |
| RIDADR | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | RY7535000 |
| HazardClass | 6.1(a) |
| PackingGroup | II |
| HS Code | 29349990 |
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
| Hazard Classifications | Acute Tox. 2 Oral |
| Toxicity | LD50 orl-mus: 10 mg/kg 41KEAL -,108,78 |
