methyl4-methyl-3-[2-(propylamino)propanoylamino]thiophene-2-carboxylate , 23964-58-1

CAS NO.：23964-58-1

Empirical Formula: C13H20N2O3S

Molecular Weight: 284.37

MDL number: MFCD00190157

EINECS: 607-295-0

PRODUCT Properties

• Melting point: 175-176 °C
• Boiling point: bp0.3 162-167°
• Density: 1.178±0.06 g/cm3(Predicted)
• storage temp.: Refrigerator
• solubility: DMSO (Slightly), Methanol (Slightly)
• pka: 13.46±0.70(Predicted)
• form: Solid
• color: White to Off-White
• Major Application: pharmaceutical (small molecule)
• InChI: InChI=1S/C13H20N2O3S/c1-5-6-14-9(3)12(16)15-10-8(2)7-19-11(10)13(17)18-4/h7,9,14H,5-6H2,1-4H3,(H,15,16)
• InChIKey: QTGIAADRBBLJGA-UHFFFAOYSA-N
• SMILES: C1(C(OC)=O)SC=C(C)C=1NC(=O)C(NCCC)C
• CAS DataBase Reference: 23964-58-1(CAS DataBase Reference)

Description and Uses

Articaine [4-methyl-3-(2-propylaminopropionamido) thiophene-2-carboxylic acid methyl ester hydrochloride] has been widely used in dentistry since its approval by the U.S. FDA in the year 2000 because of its quick onset and short duration of action. The structure of articaine differs from those of all other amino amide-type local anesthetics in that it contains a thiophene ring instead of a benzene ring and a carbomethoxy group. This renders the molecule more lipophilic and, thus, easier to cross any lipoidal membranes.
Its local anesthetic potency is approximately 1.5-fold that of lidocaine, even though it has similar pKa (7.8) and plasma protein binding (76%) properties. Articaine also is metabolized primarily by plasma cholinesterases because of the presence of an ester group and, therefore, has a much shorter duration of action than lidocaine (i.e., only approximately one-fourth that of lidocaine). Articaine undergoes rapid hydrolysis of the carbomethoxy group to give articainic acid, which is eliminated either unchanged (75%) or as its glucuronides (25%). Compared with to other shortacting, amino amide-type local anesthetics, such as mepivacaine, lidocaine, or prilocaine, articaine is said to be a much safer drug for regional anesthesia and is the drug of choice for dental procedures.

Articaine is an amide that also contains an ester linkage, which is hydrolysed rapidly so that the duration of action is short. It is available as a 4% solution with adrenaline for infiltration anaesthesia in dentistry.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P301+P312+P330
• WGK Germany: WGK 3
• HS Code: 2934990002
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Acute Tox. 4 Oral