LN9813546
concanamycinA , 95% , 80890-47-7
Synonym(s):
Concanamycin A;Folimycin;Folimycin, Streptomyces sp. - CAS 80890-47-7 - Calbiochem
CAS NO.：80890-47-7
Empirical Formula: C46H75NO14
Molecular Weight: 866.09
MDL number: MFCD00210037
EINECS: 620-709-4
| Pack Size | Price | Stock | Quantity |
| 100ug | RMB5734.40 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 179-180℃ (dichloromethane ethanol ) |
| Boiling point: | 966.4±65.0 °C(Predicted) |
| Density | 1.20±0.1 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | Soluble in DMSO |
| form | Lyophilized solid |
| pka | 12.46±0.70(Predicted) |
| color | White |
| BRN | 3560277 |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
| InChIKey | DJZCTUVALDDONK-NZJBBTFCNA-N |
| SMILES | CCC1C(O)C(C)C\C(C)=C\C=C\C(OC)C(OC(=O)\C(OC)=C\C(C)=C\C(C)C1O)C(C)C(O)C(C)[C@]2(O)C[C@@H](O[C@H]3C[C@@H](O)[C@H](OC(N)=O)[C@@H](C)O3)[C@H](C)C(O2)\C=C\C |
Description and Uses
Concanamycin A (80890-47-7) is a potent and specific inhibitor of the vacuolar (V-type) H+-ATPase which can induce apoptotic cell death in various cell lines.1,2?Inhibits cell surface expression of virus envelope glycoproteins.3?Dramatically increases the rate of extracellular vesicle release from a variety of cell types.4?Inhibits autophagy by blocking lysosomal acidification.5
Concanamycin A has been used:
- as a lysosomal inhibitor in young and old fibroblasts
- as a vacuolar-type H+-ATPase inhibitor in presynaptic vesicles
- as a lysosomal acidification blocker in HepG2 hepatocytes cells
Safety
| Symbol(GHS) |  GHS06 |
| Signal word | Danger |
| Hazard statements | H300+H310+H330-H319 |
| Precautionary statements | P262-P280-P301+P310+P330-P302+P352+P310-P304+P340+P310-P305+P351+P338 |
| PPE | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
| Hazard Codes | T+ |
| Risk Statements | 26/27/28-36 |
| Safety Statements | 26-36/37/39-45 |
| RIDADR | UN 3462 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | CB9732000 |
| F | 10-21 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 2941900000 |
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
| Hazard Classifications | Acute Tox. 1 Inhalation Acute Tox. 2 Dermal Acute Tox. 2 Oral Eye Irrit. 2 |
