BMS806 , 99% , 357263-13-9
| Pack Size | Price | Stock | Quantity |
| 1mg | RMB536.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 236 °C |
| Density | 1.328 |
| storage temp. | Store at -20°C |
| solubility | insoluble in H2O; insoluble in EtOH; ≥20.2 mg/mL in DMSO |
| form | solid |
| pka | 11.99±0.40(Predicted) |
| color | White to off-white |
| InChI | 1S/C22H22N4O4/c1-14-13-25(21(28)15-6-4-3-5-7-15)10-11-26(14)22(29)19(27)16-12-24-20-18(16)17(30-2)8-9-23-20/h3-9,12,14H,10-11,13H2,1-2H3,(H,23,24)/t14-/m1/s1 |
| InChIKey | OKGPFTLYBPQBIX-CQSZACIVSA-N |
| SMILES | O=C(N1[C@@H](CN(CC1)C(C2=CC=CC=C2)=O)C)C(C3=CNC4=NC=CC(OC)=C34)=O |
Description and Uses
BMS-806 is a small molecule that inhibits the first step of HIV-1 infection by blocking the binding of host cell CD4 with viral gp120 protein. It binds the exterior envelope glycoprotein gp120 (Kd= 21.1 nM; Ki = 24.9 nM), blocking the conformational change that occurs with CD4 binding and preventing fusion of the viral and target cell membranes. BMS-806 is specific to HIV-1 irrespective of chemokine receptor preference, with no activity against HIV-2, SIV, or a panel of additional viruses.
BMS 806 is a small molecular inhibitor of HIV-1 virus which blocks the interaction between gp120 and CD4 cells.
Safety
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
