M0838335
CRA-024781 , 97% , 783355-60-2
CAS NO.：783355-60-2
Empirical Formula: C21H23N3O5
Molecular Weight: 397.42
MDL number: MFCD10565969
EINECS: 811-183-9
| Pack Size | Price | Stock | Quantity |
| 1mg | RMB505.60 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 198-202oC (dec.) |
| Density | 1.284 |
| storage temp. | Refrigerator |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
| form | Solid |
| pka | 9.04±0.10(Predicted) |
| color | White |
| InChI | 1S/C21H23N3O5/c1-24(2)13-17-16-5-3-4-6-18(16)29-19(17)21(26)22-11-12-28-15-9-7-14(8-10-15)20(25)23-27/h3-10,27H,11-13H2,1-2H3,(H,22,26)(H,23,25) |
| InChIKey | MAUCONCHVWBMHK-UHFFFAOYSA-N |
| SMILES | N(O)C(=O)c1ccc(cc1)OCCNC(=O)c2[o]c3c(c2CN(C)C)cccc3 || CN(C)CC1=C(C(NCCOC2=CC=C(C(NO)=O)C=C2)=O)OC3=CC=CC=C31 |
Description and Uses
PCI-24781 is a novel hydroxamic acid HDAC inhibitor (histone deacetylase inhibitor). ?PCI-24781 exerts cytotoxicity and histone H3 alterations via caspase-8 and FADD in leukemia cells.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Storage Class | 11 - Combustible Solids |
