CAY-10410 , ≥98% , 596104-94-8

CAS NO.：596104-94-8

Empirical Formula: C20H30O3

Molecular Weight: 318.45

MDL number: MFCD03412003

PRODUCT Properties

• storage temp.: Store at -20°C
• solubility: DMF: 100 mg/ml; DMSO: 20 mg/ml; Ethanol: 75 mg/ml; PBS (7.2): 2.7 mg/ml

Description and Uses

CAY10410 is an analog of prostaglandin D₂/prostaglandin J₂ (PGD₂/PGJ₂) with structural modifications intended to give it PPARγ ligand activity and resistance to metabolism. 15-deoxy-Δ^12,14-PGJ₂ has been shown to be a potent ligand for PPARγ.¹ Metabolism of the cyclopentenone prostaglandins PGA₂, PGJ₂, and Δ¹²-PGJ₂ occurs via glutathione addition across the α,β unsaturated enone.² CAY10410 was designed as an analog of the PPARγ-binding prostaglandins which could not undergo this conjugation reaction. In human neuroblastoma SH-SY5Y cells, CAY10410 was not cytotoxic at up to 25 μM. It also failed to covalently modify thioredoxin or induce oxidative stress at 50 μM.³

CAY10410 (11-Oxo-prosta-5Z), a 15d-PGJ2 analog, is a potent PPARγ agonist. CAY10410 has the ability to activate PPARγ in human B cells without killing B lymphocytes[1].

Safety

• Symbol(GHS): GHS02,GHS07
• Signal word: Danger
• Hazard statements: H225-H319-H336
• Precautionary statements: P210-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501