M0908135
CM-579? , 98% , 1846570-40-8
CAS NO.：1846570-40-8
Empirical Formula: C29H40N4O3
Molecular Weight: 492.65
MDL number: MFCD31813701
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB2280.00 | In Stock |
|
| 10mg | RMB3556.80 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Boiling point: | 641.8±55.0 °C(Predicted) |
| Density | 1.143±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| pka | 10.09±0.20(Predicted) |
Description and Uses
CM-579 is a first-in-class reversible, dual inhibitor of G9a and DNMT, with IC50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells[1].
The Kd of CM-579 for DNMT1 is 1.5 nM, CM-579 also inhibits DNMT3A and DNMT3B, with IC50s of 92 nM and 1000 nM, respectively[1].
CM-579 is a first-in-class reversible, dual inhibitor of G9a and DNMT, with IC50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells[1].