M0919135
Carvedilolmetabolite4-HydroxyphenylCarvedilol , 98% , 142227-49-4
Synonym(s):
4′-Hydroxy carvedilol;4′-Hydroxyphenyl carvedilol;4′-OH carvedilol;4′OH-CVD;4-(2-(3-(9H-carbazol-4-yloxy)-2-hydroxypropylamino)ethoxy)-3-methoxyphenol
| Pack Size | Price | Stock | Quantity |
| 2mg | RMB1459.20 | In Stock |
|
| 5mg | RMB2280.00 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 163-165°C |
| Boiling point: | 702.0±60.0 °C(Predicted) |
| Density | 1.305±0.06 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 9.94±0.20(Predicted) |
| color | White to Light Brown |
| InChI | 1S/C24H26N2O5/c1-29-23-13-16(27)9-10-21(23)30-12-11-25-14-17(28)15-31-22-8-4-7-20-24(22)18-5-2-3-6-19(18)26-20/h2-10,13,17,25-28H,11-12,14-15H2,1H3 |
| InChIKey | ZCJHEORDHXCJNB-UHFFFAOYSA-N |
| SMILES | [nH]1c2c(c4c1cccc4)c(ccc2)OCC(O)CNCCOc3c(cc(cc3)O)OC |
Description and Uses
4’-hydroxyphenyl Carvedilol is a metabolite of carvedilol that is a more potent β-adrenergic receptor antagonist than carvedilol but has weaker vasodilatory activity. It is formed through oxidation primarily by the cytochrome P450 (CYP) isoform CYP2D6. 4’-hydroxyphenyl Carvedilol inhibits the formation of DPPH radicals in a cell-free assay.
A metabolite of Carvedilol (C184625). It is used in the treatment of hypertension.
Safety
| Symbol(GHS) |   GHS08,GHS09 |
| Signal word | Warning |
| Hazard statements | H373-H411 |
| Precautionary statements | P260-P273-P314-P391-P501 |
| target organs | Liver,spleen,Uterus (including cervix),Adrenal gland |
| WGK Germany | WGK 3 |
| HS Code | 9999999999 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Aquatic Chronic 2 STOT RE 2 |
