DL-Aminoglutethimide , ≥98% , 125-84-8

Synonym(s):
DL-Aminoglutethimide;3-(p-Aminophenyl)-3-ethylpiperidine-2,6-dione;3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione

CAS NO.：125-84-8

Empirical Formula: C13H16N2O2

Molecular Weight: 232.28

MDL number: MFCD00010122

EINECS: 204-756-4

PRODUCT Properties

• Melting point: 152-154 °C(lit.)
• Boiling point: 374.44°C (rough estimate)
• Density: 1.1099 (rough estimate)
• refractive index: 1.6450 (estimate)
• storage temp.: 2-8°C
• solubility: H₂O: 0.2 mg/mL, slightly soluble
• pka: 11.60±0.40(Predicted)
• form: Solid
• color: white
• biological source: synthetic
• Water Solubility: Soluble in water (2 mg/ml at 20°C), methanol (50 mg/ml), ethanol (7 mg/ml at 25°C), DMSO (20 mg/ml at 25°C), and chloroform.
• Merck: 14,440
• CAS DataBase Reference: 125-84-8(CAS DataBase Reference)
• NIST Chemistry Reference: Aminoglutethimide(125-84-8)
• EPA Substance Registry System: Aminoglutethimide (125-84-8)

Description and Uses

Aminoglutethimide is an aromatase inhibitor (IC₅₀ = 7.5 μM). Aromatase inhibitors, including aminoglutethimide, inhibit estrogen synthesis via aromatase, suppressing estrogen levels in post-menopausal women. Formulations containing aromatase inhibitors have been used to treat estrogen receptor-positive breast cancer in post-menopausal women.

aromatase inhibitor, antineoplastic, testosterone suppressant

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: 3249
• WGK Germany: 3
• RTECS: MA4026950
• HazardClass: 6.1(b)
• PackingGroup: III
• HS Code: 2925190100
• Hazardous Substances Data: 125-84-8(Hazardous Substances Data)