PRODUCT Properties
| Melting point: | 230-231 °C(lit.) |
| Boiling point: | 520.5±50.0 °C(Predicted) |
| Density | 1.05±0.1 g/cm3(Predicted) |
| storage temp. | -20°C Freezer, Under inert atmosphere |
| solubility | Chloroform (Slightly, Sonicated), Methanol (Slightly) |
| pka | 15.09±0.10(Predicted) |
| form | Solid |
| color | White to Off-White |
| Water Solubility | insoluble in water |
| BRN | 2340203 |
| InChIKey | PSZDOEIIIJFCFE-MMIPUHLFNA-N |
| SMILES | [C@@]12(C)CC[C@@]3(CO)CCC(C)(C)C[C@@]3([H])C1=CC[C@]1([H])[C@@]3(C)CC[C@H](O)C(C)(C)[C@]3([H])CC[C@@]21C |&1:0,4,13,18,20,24,29,33,r| |
| LogP | 9.180 (est) |
| CAS DataBase Reference | 545-48-2(CAS DataBase Reference) |
Description and Uses
Erythrodiol is a triterpene that has been found in olive oil and has diverse biological activities. It induces relaxation of isolated rat aortic rings precontracted with phenylephrine (EC50 = 3.38 μM). Erythrodiol inhibits the growth of HT-29 adenocarcinoma cells (EC50 = 48.8 μM). It induces production of reactive oxygen species (ROS) and apoptosis in MCF-7 cells when used at a concentration of 100 μM. Topical administration of erythrodiol (0.5 mg/ear) reduces ear edema and myeloperoxidase (MPO) activity induced by phorbol 12-myristate 13-acetate (TPA; ) in mice.
It is an essential reagent in the synthesis of aminopropoxytriterpenoids that have anticancer activity. 3β-Erythrodiol has pharmacological property as a vasodilatory agent. It may have interesting therapeutic potential as a new vasodilator drug, for protecting the cardiovascular system.
