GS-5816 , 99% , 1377049-84-7

CAS NO.：1377049-84-7

Empirical Formula: C49H54N8O8

Molecular Weight: 883

MDL number: MFCD28411371

EINECS: 1592732-453-0

PRODUCT Properties

• Melting point: >170oC (dec.)
• Density: 1.314±0.06 g/cm3(Predicted)
• storage temp.: -20°C
• solubility: Soluble in DMSO (>25 mg/ml)
• form: solid
• pka: 10.75±0.46(Predicted)
• color: Pale yellow
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
• InChIKey: FHCUMDQMBHQXKK-CDIODLITSA-N
• SMILES: C(OC)(=O)N[C@H](C1=CC=CC=C1)C(N1C[C@@H](COC)C[C@H]1C1NC(C2=CC=C3C4C(OCC3=C2)=CC2=C3C(=CC=C2C=4)N=C([C@@H]2CC[C@H](C)N2C(=O)[C@@H](NC(OC)=O)C(C)C)N3)=CN=1)=O

Description and Uses

Velpatasvir (1377049-84-7) is an extremely potent pan-genotypic hepatitis C virus (HCV) NS5A inhibitor.1 It is a component of Epclusa? and Vosevi?, two clinically useful medications with 98% and 97%, respectively, cure rates for HCV.? It displayed EC50’s for GTs 1-4, 6a ranging from 6-16 pM, GT5a at 75 pM, and GT6e at 130 pM. Velpatasvir also displayed an excellent barrier to viral resistance. It has been shown in silico, that velpatasvir binds to the SARS-CoV-2 spike protein and may be a potential therapeutic.2

Velpatasvir is a NS5A inhibitor in patients with hepatitis C (HCV) infection.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H413