M2818835
Guan-fubaseA , Analysis of the control products,> 98%, from the roots of the yellow flowers) , 1394-48-5
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB480.00 | In Stock |
|
| 20mg | RMB1454.40 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Boiling point: | 541.5±50.0 °C(Predicted) |
| Density | 1.43±0.1 g/cm3(Predicted) |
| storage temp. | 4°C, away from moisture and light |
| pka | 12.97±0.70(Predicted) |
| form | Solid |
| color | White to off-white |
| InChIKey | OGNUSOJAYIHLNS-UFZRWAKRNA-N |
| SMILES | O[C@]12[C@@H]([C@]3([H])C(=C)CC41C[C@@]1([H])[C@]5([H])[C@]6(C[C@H](OC(=O)C)C[C@]5([C@]4([H])[C@@H]3O)C2N1C6)C)OC(=O)C |&1:1,2,3,10,12,14,16,22,23,25,r| |
Description and Uses
Guanfu base A is an antiarrhythmic alkaloid isolated from Aconitum coreanum and is a potent noncompetitive CYP2D6 inhibitor, with a Ki of 1.20 μM in human liver microsomes (HLMs) and a Ki of 0.37 μM for the human recombinant form (rCYP2D6). Guanfu base A is also a potent competitive inhibitor of CYP2D in monkey (Ki of 0.38 μM) and dog (Ki of 2.4 μM) microsomes[1]. Guanfu base A also inhibits HERG channel current[2].
