Indiplon , 98% , 325715-02-4

CAS NO.：325715-02-4

Empirical Formula: C20H16N4O2S

Molecular Weight: 376.43

MDL number:

PRODUCT Properties

• Melting point: >192oC (dec.)
• Density: 1.35±0.1 g/cm3(Predicted)
• storage temp.: Store at +4°C
• solubility: Chloroform (Slightly), Ethyl Acetate (Slightly, Heated)
• pka: -1.42±0.50(Predicted)
• form: Solid
• color: Light Yellow to Dark Yellow
• InChI: 1S/C20H16N4O2S/c1-13(25)23(2)15-6-3-5-14(11-15)17-8-9-21-20-16(12-22-24(17)20)19(26)18-7-4-10-27-18/h3-12H,1-2H3
• InChIKey: CBIAWPMZSFFRGN-UHFFFAOYSA-N
• SMILES: [s]1c(ccc1)C(=O)c2c3[n](nc2)C(=CC=N3)c4cc(ccc4)N(C)C(=O)C

Description and Uses

Indiplon is a pyrazolopyrimidine that acts as a high-affinity positive allosteric modulator of the GABA_A receptor, potentiating GABA-activated chloride currents in a dose-dependent and reversible manner. Indiplon is selective for α₁ subunits (EC₅₀ = 2.6 nM) as compared with α₂, α₃, or α₅ (EC₅₀ = 24, 60, and 77 nM). Through this action, indiplon has sedative and hypnotic effects that can improve sleep onset, maintenance, and duration.

Indiplon is a member of pyrimidines with sedative, hypnotic. Indiplon has been used in trials studying the treatment of Insomnia and Depression.

Safety

• WGK Germany: WGK 3
• Storage Class: 11 - Combustible Solids