LCZ696 , 98% , 936623-90-4

CAS NO.：936623-90-4

Empirical Formula: C48H58N6O8

Molecular Weight: 847.03

MDL number: MFCD29477717

EINECS: 000-000-0

PRODUCT Properties

• storage temp.: Store at -20°C
• solubility: ≥45.05 mg/mL in DMSO; ≥11.28 mg/mL in H2O; ≥28.5 mg/mL in EtOH
• form: solid
• color: White to light yellow
• InChIKey: XTKIDERFOUYBDE-NOFROVMTNA-N
• SMILES: C(C1C=CC(C2C=CC=CC=2C2=NN=NN2)=CC=1)N(C(=O)CCCC)[C@H](C(=O)O)C(C)C.C(C1C=CC(C2C=CC=CC=2)=CC=1)[C@@H](NC(=O)CCC(=O)O)C[C@@H](C)C(=O)OCC |&1:25,45,55,r|

Description and Uses

LCZ696 is a dual angiotensin II receptor antagonist and neprilysin inhibitor that is a combination of the nonpeptide angiotensin II receptor antagonist valsartan and AHU377 , a prodrug of LBQ657 , which is an inhibitor of the zinc metallopeptidase neprilysin., LCZ696 (2-60 mg/kg) induces a dose-dependent decrease in mean arterial pressure in rats expressing human renin and angiotensinogen, a double-transgenic model for angiotensin II-dependent hypertension. Formulations containing LCZ696 are under clinical investigation for the treatment of mild to moderate hypertension and chronic heart failure.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302+H312-H315+H320