Propargyl-PEG4-CH2CH2-Boc , 97% , 1245823-50-0

CAS NO.：1245823-50-0

Empirical Formula: C18H32O7

Molecular Weight: 360.44

MDL number: MFCD22201534

PRODUCT Properties

• Boiling point: 420.6±40.0 °C(Predicted)
• Density: 1.045±0.06 g/cm3(Predicted)
• storage temp.: Storage temp. 2-8°C
• form: Liquid
• color: Colorless to light yellow

Description and Uses

Propargyl-PEG5-t-butyl ester has one of the functional groups protected by t-butyl group. The protection can be removed under acidic conditions. The propargyl group forms triazole linkages with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry. The PEG units help improving the water-solubility of the molecule in aqueous media.

Propargyl-PEG4-CH2CH2-Boc is a non-cleavable ADC linker that can be used to synthesize ADC inhibitors of Galectin-3. Propargyl-PEG4-CH2CH2-Boc is a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG4-CH2CH2-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319
• Precautionary statements: P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313