TimosaponinA1 , ≥90% , 68422-00-4
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB1264.00 | In Stock |
|
| 20mg | RMB3656.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Boiling point: | 695.5±55.0 °C(Predicted) |
| Density | 1.26±0.1 g/cm3 (20 ºC 760 Torr) |
| solubility | DMSO: 10 mM |
| form | A solid |
| pka | 12.91±0.70(Predicted) |
| color | White to off-white |
Description and Uses
Timosaponin A1 exhibits a wide spectrum of bioactivities. Also, it is a metabolite of Timosaponin A3 (T444695), which suppresses certain human tumor processes and has the potential to be developed as an anticancer agent. Reverses multi-drug resistance in human chronic myelogenous leukemia K562/ADM cells via downregulation of MDR1 and MRP1 expression by inhibiting PI3K/Akt signaling pathway. Induction of mitochondrial-dependent apoptosis in HepG2 human hepatocellular carcinoma cells.Timosaponin A3 is a potent inhibitor of U46619, that induces rat platelet aggregation and exhibited superior selectivity for the TP receptor vs. other G protein-coupled receptors and a PKC activator.
