M3783357
Eurycomalactone , ≥90% , 23062-24-0
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB3840.00 | In Stock |
|
| 10mg | RMB7200.00 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 267～270℃ |
| Boiling point: | 588.1±50.0 °C(Predicted) |
| Density | 1.328±0.06 g/cm3(Predicted) |
| storage temp. | 4°C, protect from light |
| solubility | Soluble in DMSO |
| form | Solid |
| pka | 12.22±0.70(Predicted) |
| color | White to off-white |
Description and Uses
Eurycomalactone is an active quassinoid could be isolated from Eurycoma longifolia Jack. Eurycomalactone is a potent NF-κB inhibitor with an IC50 value of 0.5 μM. Eurycomalactone inhibits protein synthesis and depletes cyclin D1. Eurycomalactone enhances radiosensitivity through arrest cell cycle at G2/M phase and delayed DNA double-strand break repair. Eurycomalactone inhibits the activation of AKT/NF-κB signaling, induces apoptosis and enhances chemosensitivity to Cisplatin (HY-17394)[1][2][3].
