4-Methyl-7-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-2H-chromen-2-one , 95% , 17833-43-1

Synonym(s):
4-Methylumbelliferyl α-D-glucoside;4-Methylumbelliferyl-α-D-glucopyranoside - CAS 17833-43-1 - Calbiochem;4-MU-α-D-Glc

CAS NO.：17833-43-1

Empirical Formula: C16H18O8

Molecular Weight: 338.31

MDL number: MFCD00067661

EINECS: 241-794-0

PRODUCT Properties

• Melting point: 171-173 °C
• Boiling point: 626.9±55.0 °C(Predicted)
• Density: 1.522±0.06 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: DMSO: 50 mg/mL, clear, colorless to faintly yellow
• form: White solid
• pka: 12.73±0.70(Predicted)
• color: White to Off-White
• BRN: 1690776
• InChI: InChI=1/C16H18O8/c1-7-4-12(18)23-10-5-8(2-3-9(7)10)22-16-15(21)14(20)13(19)11(6-17)24-16/h2-5,11,13-17,19-21H,6H2,1H3/t11-,13-,14+,15-,16+/s3
• InChIKey: YUDPTGPSBJVHCN-JZYAIQKZSA-N
• SMILES: C12OC(C=C(C)C=1C=CC(O[C@@H]1[C@H](O)[C@H]([C@H](O)[C@@H](CO)O1)O)=C2)=O |&1:11,12,14,15,17,r|
• CAS DataBase Reference: 17833-43-1(CAS DataBase Reference)

Description and Uses

4-Methylumbelliferyl-α-D-glucopyranoside is a fluorogenic substrate for α-glucosidase. 4-Methylumbelliferyl-α-D-glucopyranoside is cleaved by α-glucosidase to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high pH (7.12-10.3), respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases. 4-Methylumbelliferyl-α-D-glucopyranoside has been used to quantify α-glucosidase activity in infant blood spot samples as a biomarker of Fabry and Pompe diseases, lysosomal storage disorders characterized by a deficiency in the enzyme.

4-Methylumbelliferyl α-D-glucopyranoside is used as a flurogenic substrate for the identification, characterization and kinetic analysis of α-D-glucosidase(s).

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P301+P312-P302+P352-P304+P340-P305+P351+P338
• Safety Statements: 22-24/25
• WGK Germany: 3
• F: 3-10-21
• HS Code: 2932209090