Novobiocin , 95% , 303-81-1
Synonym(s):
Benzamide, N-[7-[[3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-?-l-lyxohexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-
(3-methyl-2-butenyl), monohydrate;Streptonivicin
CAS NO.：303-81-1
Empirical Formula: C31H36N2O11
Molecular Weight: 612.62
MDL number:
EINECS: 206-146-3
| Pack Size | Price | Stock | Quantity |
| 1g | RMB6479.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 170-172 °C |
| alpha | D24 -63.0° (c = 1 in ethanol) |
| Boiling point: | 657.29°C (rough estimate) |
| Density | 1.3448 |
| refractive index | 1.5800 (estimate) |
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | pKa1 4.3; pKa2 9.1(at 25℃) |
| color | White to Pale Yellow |
Description and Uses
Novobiocin (Albamycin, Cathamycin, Spheromycin) is an aminocoumarin antibiotic originally isolated from Streptomyces niveus in the Upjohn Research Laboratories and initially was given the generic name of ‘streptonivicin’ . It was also isolated almost simultaneously in other laboratories, and was given several other names. Novobiocin inhibits the GyrB subunit of DNA gyrase and is primarily active against Gram-positive microorganisms. It was used under the trade name Albamycin and was withdrawn from the market in the US. Its latest use included eradication of methicillin-resistant Staphylococcus aureus (MRSA) and other resistant microorganisms. In addition, it has been applied in cancer therapy.
Novobiocin is an aminocoumarin antibiotic used in the treatment of Staphylococcus epidermis.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H317 |
| Precautionary statements | P280-P301+P312+P330 |
| WGK Germany | 3 |
| HS Code | 2941906000 |
| Hazardous Substances Data | 303-81-1(Hazardous Substances Data) |
