Nolatrexeddihydrochloride , BR , 152946-68-4

CAS NO.：152946-68-4

Empirical Formula: C14H14Cl2N4OS

Molecular Weight: 357.26

MDL number: MFCD00917041

EINECS: 680-267-3

PRODUCT Properties

• Melting point: 301-3020C
• storage temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• solubility: Methanol, Water
• form: Solid
• pka: 4.1; 5.9; 9.8(at 25℃)
• color: Off-White to Pale Yellow
• Water Solubility: H2O: 2mg/mL, clear
• Stability: Hygroscopic
• InChI: 1S/C14H12N4OS.2ClH/c1-8-2-3-10-11(13(19)18-14(15)17-10)12(8)20-9-4-6-16-7-5-9;;/h2-7H,1H3,(H3,15,17,18,19);2*1H
• InChIKey: PJKVJJYMWOCLIJ-UHFFFAOYSA-N
• SMILES: NC1=NC(C2=C(N1)C=CC(C)=C2SC3=CC=NC=C3)=O
• CAS DataBase Reference: 152946-68-4(CAS DataBase Reference)

Description and Uses

Antifolate thymidylate synthase inhibitor. Antineoplastic.

Safety

• Symbol(GHS): GHS08
• Signal word: Warning
• Hazard statements: H361-H341
• Precautionary statements: P201-P202-P281-P308+P313-P405-P501-P201-P202-P281-P308+P313-P405-P501
• WGK Germany: WGK 3
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Muta. 2; Repr. 2