Potassiumclavulanate , 1: 1 ratio , 61177-45-5
Synonym(s):
Clavulanate potassium
CAS NO.：61177-45-5
Empirical Formula: C8H10KNO5
Molecular Weight: 239.27
MDL number: MFCD01710901
EINECS: 262-640-9
| Pack Size | Price | Stock | Quantity |
| 5g | RMB64.00 | In Stock |
|
| 25g | RMB252.80 | In Stock |
|
| 100g | RMB944.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | >1600C (dec) |
| alpha | +55～+60° |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Freely soluble in water, slightly soluble in ethanol (96 per cent), very slightly soluble in acetone. |
| form | Solid |
| color | Light brown to brown |
| Major Application | agriculture clinical environmental forensics and toxicology pharmaceutical (small molecule) |
| InChI | InChI=1/C8H9NO5.K.H/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4;;/h1,6-7,10H,2-3H2,(H,12,13);;/b4-1-;;/t6-,7-;;/s3 |
| InChIKey | ABVRVIZBZKUTMK-JSYANWSFSA-M |
| SMILES | C([C@H]1/C(/O[C@]2([H])CC(=O)N12)=C/CO)(=O)O.[KH] |&1:1,4,r| |
| CAS DataBase Reference | 61177-45-5(CAS DataBase Reference) |
Description and Uses
Clavulanate is a β-lactamase inhibitor that is effective against Ambler class A β-lactamases (IC50 values range from 12 to 60 nM). While it is not an effective antibiotic by itself, clavulanate is commonly used with other antibiotics that would be inactivated by β-lactamases secreted by bacteria. It is often combined with amoxicillin and other penicillin-based antibiotics.
Clavulanic acid is a β-lactam antibiotic produced by several species of Streptomyces. The free acid degrades and is isolated and maintained as either the sodium or potassium salt. Clavulanate is a weak antibiotic, but is a potent inhibitor of β-lactamases. In combination with penicillin and cephalosporins, it shows potent synergistic activity. Clavulanic acid is a suicide inhibitor, covalently binding to a serine residue in the active site of the β-lactamase.
Safety
| Symbol(GHS) |   GHS02,GHS08 |
| Signal word | Danger |
| Hazard statements | H228-H252-H317-H334 |
| Precautionary statements | P210-P235-P280-P302+P352-P304+P340+P312-P403+P235 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| Hazard Codes | F,Xn,Xi |
| Risk Statements | 11-42/43-44-36-14 |
| Safety Statements | 8-16-22-36/37-45-43-26 |
| RIDADR | UN1325 - class 4.1 - PG 2 - Flammable solids, organic, n.o.s., HI: all |
| WGK Germany | 2 |
| RTECS | RN6802700 |
| HS Code | 2941900000 |
| Storage Class | 4.2 - Pyrophoric and self-heating hazardous materials |
| Hazard Classifications | Flam. Sol. 2 Resp. Sens. 1 Self-heat. 2 Skin Sens. 1 |
