Senegenin , ≥98%(HPLC) , 2469-34-3
Synonym(s):
12-(Chloromethyl)-2,3-dihydroxy-27-norolean-13-ene-23,28-dioic acid;Tenuigenin
| Pack Size | Price | Stock | Quantity |
| 20mg | RMB745.60 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 290-292℃ |
| alpha | D +19° (c = 0.70 in ethanol) |
| Boiling point: | 674.1±55.0 °C(Predicted) |
| Density | 1.28 |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble10mg/mL, clear |
| pka | 4.27±0.70(Predicted) |
| form | powder |
| color | white to beige |
| InChIKey | CWHJIJJSDGEHNS-JEKQWPLRNA-N |
| SMILES | C[C@]12C[C@H](O)[C@H](O)[C@@](C)(C(=O)O)[C@]1([H])CC[C@]1(C3CC[C@]4(CCC(C)(C)C[C@@]4([H])C=3[C@@H](CCl)C[C@]21[H])C(=O)O)C |&1:1,3,5,7,12,16,20,27,30,34,r| |
Description and Uses
Tenuigenin is a triterpenoid sapogenin that has been found in P. tenuifolia and has diverse biological activities, including antioxidant, anti-inflammatory, and neuroprotective properties. It inhibits IL-1β and reactive oxygen species (ROS) production from LPS-induced mouse BV2 microglia at a concentration of 4 μM. Tenuigenin (25 mg/kg per day) decreases NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome activation and prevents dopaminergic neuronal degeneration in the mouse substantia nigra pars compacta in an MPTP-induced model of Parkinson''s disease. Tenuigenin (2 mg/kg) also reduces increases in lung edema and the levels of IL-1β and TNF-α in bronchoalveolar lavage fluid (BALF) in a mouse model of intranasal S. aureus-induced pneumonia.
Tenuifgenin is a Chinese herbal extract with anti-oxidative and anti-inflammatory effects involving toxin induced cell models of Parkinson’s disease.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P301+P312+P330 |
| WGK Germany | 3 |
| RTECS | RC8815000 |
| Toxicity | LD50 intraperitoneal in mouse: 3mg/kg |
