ε-Viniferin , 96% , 62218-08-0
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB2204.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | approximate 157℃ (dec.) |
| storage temp. | Store at -20°C |
| solubility | Soluble in methanol; |
| form | Powder |
| color | Off-white to gray |
| Water Solubility | sparingly soluble in water |
| LogP | 3.802 (est) |
Description and Uses
trans-ε-Viniferin is a stilbene polyphenol and dimer of trans-resveratrol that has been found in various red wines and has diverse biological activities. It induces disaggregation of aggregated amyloid-β (1-42) (Aβ42; ) fibrils in a cell-free assay and decreases Aβ42- and IL-1β-induced release of TNF-α and IL-6 in primary mouse neuron and astrocyte cocultures. trans-ε-Viniferin reduces cytotoxicity induced by truncated huntingtin (Htt) in PC12 cells (EC50 = 30 nM). It also reduces production of reactive oxygen species (ROS), mitochondrial dysfunction, and PGC-1α depletion and increases protein levels and deacetylase activity of sirtuin 3 (SIRT3) in cells expressing mutant Htt. trans-ε-Viniferin inhibits calcium-activated chloride channel currents in HT-29 cells (IC50 = ~1 μM). In vivo, trans-ε-viniferin (2 μg per animal) reduces rotavirus-induced secretory diarrhea in mice without affecting the rotaviral infection. Dietary administration of trans-ε-viniferin reduces hepatic triglyceride accumulation and body weight increases in a mouse model of diet-induced obesity.
ε-Viniferin is a stilbene extract posessing cytotoxic effects and may contain anti-cancer properties.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
