DiOC6(3)iodide

Synonym(s):
3-hexyl-2-[3-(3-hexyl-2(3H)benzoxazolylidene)-1-propenyl]benzoxazolium iodide

CAS NO.：

Empirical Formula: C29H37IN2O2

Molecular Weight: 572.53

MDL number: MFCD00011954

PRODUCT Properties

• Melting point: 219-221 °C(lit.)
• Density: 1.2837 (estimate)
• storage temp.: room temp
• solubility: Soluble in ethanol, methanol, dimethyl sulfoxide
• form: Powder
• color: Red
• Appearance: Orange yellow solid
• ex/em: 484/501 nm (MeOH)
• ε(extinction coefficient): ≥120000 at 483-488nm in methanol at 0.01g/L
• λmax: 484 nm
• Sensitive: Light Sensitive
• BRN: 9312562
• Biological Applications: Detecting mitochondrial membrane potential,3,10–16,47,nucleic acid hybridization,prostate cancer,germination Bacillus anthracis spores; apoptosis assays; diagnostic assays; in photodynamic therapy; treating malaria,leishmaniasis,t
• CAS DataBase Reference: 53213-82-4(CAS DataBase Reference)
• EPA Substance Registry System: Benzoxazolium, 3-hexyl-2-[3-(3-hexyl-2(3H)-benzoxazolylidene)-1-propenyl]-, iodide (53213-82-4)

Description and Uses

3,3'-Dihexyloxacarbocyanine is a cell-permeable green fluorescent dye that is used as a membrane potential probe. At high concentrations, 3,3'-Dihexyloxacarbocyanine accumulates in the endoplasmic reticulum (ER) and has been used to visualize ER in moss, yeast, and muscle cells. At low concentrations, it accumulates in mitochondria and has been used to assess mitochondrial dislocations, fusion, and fission in living cells, as well as to visualize cellular apoptosis.

Endoplasmic Reticulum-Tracker dye is a cell-permeant, live-cell stain that is highly selective for the ER. This dye rarely stain mitochondria, unlike the conventional ER stain DiOC6(3) and staining at low concentrations does not appear to be toxic to cell

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: DM5285250
• F: 8
• TSCA: Yes
• HS Code: 29269095