DBCO-PEG4-NHSEster , 95% , 1427004-19-0

Synonym(s):
DBCO-PEG4-NHS ester;DBCO-PEG4-SE;DBCO-PEG4-succinimidyl ester

CAS NO.：1427004-19-0

Empirical Formula: C34H39N3O10

Molecular Weight: 649.69

MDL number: MFCD26793797

PRODUCT Properties

• Density: 1.33±0.1 g/cm3(Predicted)
• storage temp.: -20°C
• solubility: Soluble in DMSO, DCM, DMF
• pka: 15.14±0.46(Predicted)
• form: gel or oil
• color: Colourless to yellow
• InChIKey: RRCXYKNJTKJNTD-UHFFFAOYSA-N
• SMILES: C(ON1C(=O)CCC1=O)(=O)CCOCCOCCOCCOCCNC(=O)CCC(N1CC2=CC=CC=C2C#CC2=CC=CC=C12)=O

Description and Uses

DBCO-PEG4-NHS Ester is a click chemistry PEG reagent containing NHS ester that is able to react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond. The hydrophilic PEG spacer arm improves water solubility and provides a long and flexible connection that minimizes steric hindrance involved with ligation. DBCO is commonly used for copper-free Click Chemistry reactions.

Succinimidyl ester (NHS, amine reactive) functionalized cyclooctyne derivative for incorporation of the cyclooctyne moiety into amine containing compounds or biomolecules. Cyclooctynes are useful in strain-promoted copper-free click chemistry cycloaddition reactions. This dibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage.

Applications Include:

• Protein-peptide conjugates
• Antibody-enzyme or antibody-drug conjugates
• Protein or peptide-oligonucleotide conjugates
• Surface modification

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P305+P351+P338
• WGK Germany: 3
• HS Code: 2942000090