PRODUCT Properties
| Melting point: | 90-92 °C |
| Boiling point: | 616.9±55.0 °C(Predicted) |
| Density | 1.312±0.06 g/cm3(Predicted) |
| storage temp. | 4°C, protect from light |
| solubility | Soluble in DMSO |
| pka | 7.08±0.20(Predicted) |
| form | Solid |
| color | Brown to black |
| LogP | 2.424 (est) |
Description and Uses
Beta-hydroxyisovalerylshikonin is a natural product isolated from Lithospermum erythrorhizon, acts as a potent inhibitor of protein tyrosine kinases (PTK), with IC50s of 0.7μM and 1μM for EGFR and v-Src receptor, respectively. Beta-hydroxyisovalerylshikonin is effective against a wide variety of tumor cell lines, and most efficiently induces cell-death in NCI-H522 and DMS114 cells[1].
