Potassiumclavulanate , 98% , 61177-45-5

Synonym(s):
Clavulanate potassium

CAS NO.：61177-45-5

Empirical Formula: C8H10KNO5

Molecular Weight: 239.27

MDL number: MFCD01710901

EINECS: 262-640-9

PRODUCT Properties

• Melting point: >1600C (dec)
• alpha: +55～+60°
• storage temp.: Inert atmosphere,2-8°C
• solubility: Freely soluble in water, slightly soluble in ethanol (96 per cent), very slightly soluble in acetone.
• form: Solid
• color: Light brown to brown
• InChI: InChI=1/C8H9NO5.K.H/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4;;/h1,6-7,10H,2-3H2,(H,12,13);;/b4-1-;;/t6-,7-;;/s3
• InChIKey: ABVRVIZBZKUTMK-JSYANWSFSA-M
• SMILES: C([C@H]1/C(/O[C@]2([H])CC(=O)N12)=C/CO)(=O)O.[KH] |&1:1,4,r|
• CAS DataBase Reference: 61177-45-5(CAS DataBase Reference)

Description and Uses

Clavulanate is a β-lactamase inhibitor that is effective against Ambler class A β-lactamases (IC₅₀ values range from 12 to 60 nM). While it is not an effective antibiotic by itself, clavulanate is commonly used with other antibiotics that would be inactivated by β-lactamases secreted by bacteria. It is often combined with amoxicillin and other penicillin-based antibiotics.

Clavulanic acid is a β-lactam antibiotic produced by several species of Streptomyces. The free acid degrades and is isolated and maintained as either the sodium or potassium salt. Clavulanate is a weak antibiotic, but is a potent inhibitor of β-lactamases. In combination with penicillin and cephalosporins, it shows potent synergistic activity. Clavulanic acid is a suicide inhibitor, covalently binding to a serine residue in the active site of the β-lactamase.

Safety

• Symbol(GHS): GHS02,GHS08
• Signal word: Danger
• Hazard statements: H228-H252-H317-H334
• Precautionary statements: P210-P235-P280-P302+P352-P304+P340+P312-P403+P235
• Hazard Codes: F,Xn,Xi
• Risk Statements: 11-42/43-44-36-14
• Safety Statements: 8-16-22-36/37-45-43-26
• RIDADR: UN1325 - class 4.1 - PG 2 - Flammable solids, organic, n.o.s., HI: all
• WGK Germany: 2
• RTECS: RN6802700
• HS Code: 2941900000