PRODUCT Properties
| Melting point: | ~185 °C |
| alpha | D25 -69° (c = 0.5 in chloroform) |
| Boiling point: | 474.91°C (rough estimate) |
| Density | 1.0362 (rough estimate) |
| refractive index | 1.4700 (estimate) |
| storage temp. | Store at -20°C |
| solubility | Ethanol: ≥ 10 mg/mL (24.00 mM); DMSO: < 1 mg/mL (insoluble or slightly soluble) |
| pka | 15.14±0.70(Predicted) |
| form | Solid |
| color | White to off-white |
Description and Uses
Smilagenin (SMI) is a small-molecule steroidal sapogenin from Anemarrhena asphodeloides and Pelargonium hortorum widely used in traditional Chinese medicine for treating chronic neurodegeneration diseases[1]. Smilagenin (SMI) improves memory of aged rats by increasing the muscarinic receptor subtype 1 (M1)-receptor density[2]. Smilagenin (SMI) attenuates Aβ(25-35)-induced neurodegenerationvia stimulating the gene expression of brain-derived neurotrophic factor, may represents a novel therapeutic strategy for AD[3].
Safety
| WGK Germany | 3 |
| F | 10 |
