Tadalafil-d3 , 98% , 960226-55-5

CAS NO.：960226-55-5

Empirical Formula: C22H18N3O4

Molecular Weight: 388.396

MDL number:

PRODUCT Properties

• Melting point: 281-283°C
• storage temp.: -20°C Freezer
• solubility: Chloroform (Slightly), DMSO (Slightly)
• form: Solid
• color: White to Off-White
• Stability: Unstable in Methanol
• InChI: InChI=1/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21+/s3
• InChIKey: WOXKDUGGOYFFRN-PDIFIXMTNA-N
• SMILES: c12c3ccccc3nc1[C@H](c1cc3OCOc3cc1)N1C(=O)CN(C)C(=O)[C@H]1C2 |&1:9,27,r|

Description and Uses

Tadalafil-d₃ is intended for use as an internal standard for the quantification of tadalafil by GC- or LC-MS. Tadalafil is a potent inhibitor of phosphodiesterase 5 (PDE5; IC₅₀ = 1.2 nM). It is selective for PDE5 over PDE1-4 and 7-10 (IC₅₀s = 9.2-280 μM), however, it does also inhibit PDE11 (IC₅₀ = 11 nM). In vivo, tadalafil (10 mg/kg) decreases production of the proinflammatory cytokines TNF-α, IL-1β, and IL-6 and improves renal function in a rat model of ischemia/reperfusion injury. It also reduces development of tobacco smoke-induced emphysema and pulmonary hypertension in mice. Formulations containing tadalafil have been used to treat erectile dysfunction, pulmonary arterial hypertension, and lower urinary tract dysfunction.

Tadalafil-d3 is used for the treatment of erectile dysfunction. A phosphodiesterase 5 inhibitor. Intended for use as an internal standard for the quantification of Tadalafil by GC- or LC-mass spectrometry.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501