(+)-trans-C75 , 98% , 1234694-20-2

CAS NO.：1234694-20-2

Empirical Formula: C14H22O4

Molecular Weight: 254.32

MDL number:

PRODUCT Properties

• solubility: DMF: 30 mg/ml; DMSO: 10 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 0.5 mg/ml
• form: A crystalline solid

Description and Uses

C75 is stable fatty acid synthase (FASN) inhibitor that when administered in racemic form leads to profound weight loss and feeding inhibition in both high-fat diet wild type obese and leptin-deficient ob/ob mice. C75 is also cytotoxic to many human cancer cell lines, an effect believed to be mediated by the accumulation of malonyl-coenzyme A in cells with an upregulated FASN pathway. (+)-trans-C75 is an enantiomer of C75. Its biologicial activity has not been reported.

(+)-trans-C75 ((+)-C75) is an enantiomer of C75 (HY-12364) (a fatty acid synthase inhibitor). (+)-trans-C75 is less potent than the racemic mixture or the (-) enantiomer in enhancing the cancer-killing ability of ionizing radiation. (+)-trans-C75 inhibits CPT1 and is an anorectic agent[1][2].