Ac-LEHD-AFC , 98% , 210345-03-2

Synonym(s):
Ac-LEHD-AFC

CAS NO.：210345-03-2

Empirical Formula: C33H38F3N7O11

Molecular Weight: 765.69

MDL number: MFCD01862610

PRODUCT Properties

• Boiling point: 1211.9±65.0 °C(Predicted)
• Density: 1.457±0.06 g/cm3(Predicted)
• storage temp.: −20°C
• solubility: DMSO/DMF: 20 mM
• pka: 4.07±0.10(Predicted)
• form: powder
• color: white
• Water Solubility: Soluble to 1 mg/ml in water
• InChIKey: HULKIXRFKRCRHD-ZJZGAYNASA-N
• SMILES: FC(F)(F)C1=CC(=O)Oc2c1ccc(c2)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)CC(C)C)CCC(=O)O)Cc3[nH]cnc3)CC(=O)O

Description and Uses

Ac-LEHD-AFC Trifluoroacetic Acid Salt is a fluorogenic substrate that is cleaved by caspases (4,5 and 9). This activity is quantified by fluorescent detection of free AFC. Caspase-9 activation is critical for intrinsic cell death.

Safety

• WGK Germany: 3
• Storage Class: 11 - Combustible Solids