ACPT-I , 98% , 194918-76-8
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB1983.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Boiling point: | 440.4±45.0 °C(Predicted) |
| Density | 1.651±0.06 g/cm3(Predicted) |
| storage temp. | Desiccate at -20°C |
| solubility | Soluble to 10 mM in water and to 50 mM in 1.1eq. NaOH |
| form | Powder |
| pka | 1.85±0.60(Predicted) |
| color | White to off-white |
Description and Uses
ACPT-I is an agonist of the group III metabotropic glutamate receptors (mGluRs) mGluR4a and mGluR8 (EC50s = 7.2 and 8.2 μM, respectively) that has no effect on mGluR1a or mGluR2. It has diverse biological activity, including neuroprotective, anticonvulsant, and anxiolytic-like effects. ACPT-I (1-200 μM) reduces cell death following oxygen-glucose deprivation in primary neuronal cultures and in a rat model of middle cerebral artery occlusion when used at a dose of 30 mg/kg. It is neuroprotective against excitotoxicity induced by kainite in vitro and in vivo and reduces the incidence of clonic seizures in various seizure models in mice and rats (ED50s = 0.08-49.3 nM, i.c.v.). ACPT-I also has anxiolytic-like effects in mice and rats, however, these effects can be blocked by WAY-100635 and flumazenil , indicating the involvement of the serotonin (5-HT) receptor subtype 5-HT1A and GABAA receptor.
ACPT-I is a competitive antagonist for metabotropic receptors (mGluRs).
