(R)-(+)-Bay-K-8644 , 98% , 98791-67-4

CAS NO.：98791-67-4

Empirical Formula: C16H15F3N2O4

Molecular Weight: 356.3

MDL number: MFCD00153768

PRODUCT Properties

• Boiling point: 429.174±45.00 °C(Press: 760.00 Torr)(predicted)
• Density: 1.372±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
• storage temp.: 2-8°C
• solubility: H₂O: slightly soluble
• form: solid
• pka: -3.430±0.70(predicted)
• color: yellow

Description and Uses

BAY-K-8644, originally described as a modulator of potential operated calcium channels, exists as two enantiomers that have opposite actions. (R)-(+)-BAY-K-8644 is an L-type channel blocker that has negative inotropic and vasodilatory effects at 1 μM. Intracerebroventricular administration of this enantiomer has no effect on motor function in mice, whereas (S)-(−)-BAY-K-8644 impairs rotarod and motor activity, an effect that is blocked by (R)-(+)-BAY-K-8644.

(R)-(+)-Bay K 8644 is a Ca2+ channel inhibitor, whose enantiomer is a Ca2+ channel activator.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319
• Precautionary statements: P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
• Hazard Codes: Xi
• Risk Statements: 36/38
• Safety Statements: 26-36
• WGK Germany: 3