Naltrexone , 98% , 16590-41-3

Synonym(s):
(5α)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one

CAS NO.：16590-41-3

Empirical Formula: C20H23NO4

Molecular Weight: 341.4

MDL number: MFCD00242996

EINECS: 240-649-9

PRODUCT Properties

• Melting point: 168-170°
• Boiling point: 477.03°C (rough estimate)
• Density: 1.2064 (rough estimate)
• refractive index: 1.5614 (estimate)
• Flash point: 9℃
• storage temp.: 2-8°C
• solubility: Chloroform (Slightly), Methanol (Slightly)
• pka: pKa 8.38/8.13(H2O,t =20/37,I<0.01) (Uncertain)
• form: Solid
• color: White to Light Beige
• InChI: InChI=1/C20H23NO4/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11/h3-4,11,15,18,22,24H,1-2,5-10H2/t15-,18+,19+,20-/s3
• InChIKey: DQCKKXVULJGBQN-AOJBWHFRNA-N
• SMILES: [C@@]123CCN(CC4CC4)[C@@H]4CC5=CC=C(O)C(O[C@H]1C(CC[C@]24O)=O)=C35 |&1:0,8,17,21,r|
• EPA Substance Registry System: Naltrexone (16590-41-3)

Description and Uses

This drug does not have agonistic properties. It is similar to naloxone in terms of pharmacological characteristics; however, it differs in two important ways—long-lasting action and that its metabolite 6-β-naltrexol is also a strong antagonist. Naltrexone is potentially hepatotoxic. Naltrexone is used for blocking pharmacological effects of opioids upon their overdose.

Labeled Naltrexone, intended for use as an internal standard for the quantification of Naltrexone by GC- or LC-mass spectrometry.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H336
• Precautionary statements: P261-P264-P270-P271-P301+P312-P304+P340+P312
• Hazard Codes: F,T
• Risk Statements: 11-23/24/25-39/23/24/25
• Safety Statements: 16-36/37-45
• RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
• WGK Germany: 1
• HS Code: 2939190000
• Hazardous Substances Data: 16590-41-3(Hazardous Substances Data)
• Toxicity: LD50 in mice (mg/kg): 586 s.c. (Maickel)