Poloxamer124 , EuropeanPharmacopoeia(EP)ReferenceStandard , 9003-11-6

Synonym(s):
3β,17α-Dihydroxy-5-pregnen-20-one;5-Pregnene-3β,17α-diol-20-one

CAS NO.：9003-11-6

Empirical Formula: C21H32O3

Molecular Weight: 332.48

MDL number: MFCD00021129

EINECS: 206-862-6

PRODUCT Properties

• Melting point: 273℃
• Flash point: 9℃
• storage temp.: -20°C
• solubility: Chloroform (Slightly), DMSO (Slightly, Heated, Sonicated)
• form: Solid
• Boiling point: 478.4±45.0 °C(Predicted)
• Density: 1.15±0.1 g/cm3(Predicted)
• pka: 13.02±0.70(Predicted)
• color: White to Off-White
• InChI: InChI=1S/C21H32O3/c1-13(22)21(24)11-8-18-16-5-4-14-12-15(23)6-9-19(14,2)17(16)7-10-20(18,21)3/h4,15-18,23-24H,5-12H2,1-3H3/t15-,16+,17-,18-,19-,20-,21-/m0/s1
• InChIKey: JERGUCIJOXJXHF-TVWVXWENSA-N
• SMILES: C[C@]12CC[C@]3([H])[C@]4(CC[C@@H](CC4=CC[C@@]3([H])[C@]1([H])CC[C@]2(O)C(=O)C)O)C
• CAS DataBase Reference: 387-79-1(CAS DataBase Reference)

Description and Uses

17α-hydroxy Pregnenolone is a metabolite of pregnenolone and a precursor in the biosynthesis of dehydroepiandrosterone (DHEA; ). It is formed from pregnenolone by cytochrome P450 (CYP) isoform CYP17A1 hydroxylase activity and then converted to dehydroepiandrosterone by CYP17A1-mediated 17,20-lyase activity. Plasma levels of 17α-hydroxy pregnenolone are elevated in patients with type II 3β-hydroxysteroid dehydrogenase deficiency, a form of congenital adrenal hyperplasia.

17α-hydroxypregnenolone has been used as a substrate for the enzyme 3β‐hydroxysteroid dehydrogenase (3β‐HSD) expressed in COS1 cells.

Safety

• Symbol(GHS): GHS02,GHS06,GHS08
• Signal word: Danger
• Hazard statements: H225-H301+H311+H331-H370
• Precautionary statements: P210-P260-P280-P301+P310-P311
• Hazard Codes: F,T
• Risk Statements: 11-23/24/25-39/23/24/25
• Safety Statements: 7-16-36/37-45
• RIDADR: UN1230 - class 3 - PG 2 - Methanol
• WGK Germany: 3
• RTECS: TU5548000