1.0 mg/mLinmethanol,ampuleof1 mL,certifiedreferencematerial,Cerilliant , 59467-70-8

Synonym(s):
8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine;Midazolam-d₄ maleate solution

CAS NO.：59467-70-8

Empirical Formula: C18H13ClFN3

Molecular Weight: 325.77

MDL number: MFCD08272801

EINECS: 261-774-5

Update time: 2022-07-08

PRODUCT Properties

Melting point:	161-164°C
Boiling point:	496.9±55.0 °C(Predicted)
Density	1.3136 (estimate)
Flash point:	9 °C
storage temp.	Controlled Substance, -20°C Freezer
solubility	Practically insoluble in water, freely soluble in acetone and in ethanol (96 per cent), soluble in methanol.
form	Solid:crystalline
pka	pKa 1.7±0.1;6.15± 0.1 (Uncertain)
Water Solubility	54mg/L(24 ºC)
BCS Class	1
Major Application	clinical testing
InChI	1S/C18H13ClFN3/c1-11-21-9-13-10-22-18(14-4-2-3-5-16(14)20)15-8-12(19)6-7-17(15)23(11)13/h2-9H,10H2,1H3
InChIKey	DDLIGBOFAVUZHB-UHFFFAOYSA-N
SMILES	Cc1ncc2CN=C(c3ccccc3F)c4cc(Cl)ccc4-n12
LogP	2.73
CAS DataBase Reference	59467-70-8(CAS DataBase Reference)
NIST Chemistry Reference	Midazolam(59467-70-8)

Description and Uses

Midazolam is the most commonly used parenteral sedative in anaesthetic practice. The structure of midazolam is altered by local changes in pH (tautomerism), and the two different forms confer either water or lipid solubility to the drug . At pH<4 the benzodiazepine nucleus opens because of an ionisable amine group in the molecule's structure, and this increases water solubility. At plasma pH the amine group is incorporated back into the unionised ring form of the molecule, which is highly lipid soluble and diffuses rapidly into the brain. A concentrated preparation (5mgml ?1 ) is available for i.m. injection and absorption is rapid compared with diazepam.

Anti-Depressant

Safety

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H301
Precautionary statements	P264-P270-P301+P310-P405-P501
target organs	Eyes,Central nervous system
Hazard Codes	F,T
Risk Statements	11-23/24/25-39/23/24/25
Safety Statements	7-16-36/37-45
RIDADR	3249
WGK Germany	2
HazardClass	6.1(b)
PackingGroup	III
HS Code	2933910000
Storage Class	3 - Flammable liquids
Hazard Classifications	Acute Tox. 3 Dermal Acute Tox. 3 Inhalation Acute Tox. 3 Oral Flam. Liq. 2 STOT SE 1
Hazardous Substances Data	59467-70-8(Hazardous Substances Data)
DEA Controlled Substances	CSCN: 2884 CAS SCH: IV NARC: N