pharmaceuticalsecondarystandard,certifiedreferencematerial , 54143-56-5

Synonym(s):
N-(2-Piperidylmethyl)-2,5-bis-(2,2,2-trifluoroethoxy)benzamide acetate salt;Flecainide acetate salt

CAS NO.：54143-56-5

Empirical Formula: C19H24F6N2O5

Molecular Weight: 474.39

MDL number: MFCD00214290

EINECS: 258-997-5

PRODUCT Properties

• Melting point: 145-147℃
• storage temp.: 2-8°C
• solubility: Soluble in water and in anhydrous ethanol. It is freely soluble in dilute acetic acid and practically insoluble in dilute hydrochloric acid.
• form: Solid
• color: White
• Water Solubility: Soluble in dilute acetic acid, dimethyl sulfoxide, ethanol, methanol and water.
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
• InChIKey: RKXNZRPQSOPPRN-UHFFFAOYSA-N
• SMILES: C1(C=C(C=CC=1OCC(F)(F)F)OCC(F)(F)F)C(=O)NCC1NCCCC1.C(=O)(O)C

Description and Uses

Flecainide acetate (54143-56-5) is an open Na+?channel blocker that inhibits fast Na+?current in cardiac muscle in a use- and concentration-dependent manner.1?Orally-active class Ic antiarrhythmic agent2,3. Inhibits hERG potassium channels at clinically relevant concentrations.4

Class I antiarrhythmic.

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Danger
• Hazard statements: H302-H315-H319-H335-H360FD
• Precautionary statements: P201-P202-P301+P312-P302+P352-P305+P351+P338-P308+P313
• Hazard Codes: Xn
• Risk Statements: 22-36/37/38-63
• Safety Statements: 22-26-36/37/39-45-46
• RIDADR: 3249
• WGK Germany: -
• RTECS: CV5792550
• HazardClass: 6.1(b)
• PackingGroup: III
• HS Code: 2933399090