≥95% , 6232-19-5

CAS NO.：6232-19-5

Empirical Formula: C4H6N2O2

Molecular Weight: 114.1

MDL number: MFCD00021722

PRODUCT Properties

• Melting point: 217 °C
• storage temp.: -20°C
• solubility: PBS (pH 7.2): 10 mg/ml
• form: A crystalline solid
• color: White to yellow
• InChI: 1S/C4H6N2O2/c5-2-1-3(6)4(7)8/h3H,1,6H2,(H,7,8)/t3-/m0/s1
• InChIKey: BXRLWGXPSRYJDZ-VKHMYHEASA-N
• SMILES: OC([C@@H](N)CC#N)=O

Description and Uses

Hydrogen sulfide (H₂S) is a naturally-occurring gasotransmitter with vasodilator and inflammatory modulating activity. H₂S is synthesized naturally in a range of mammalian tissues principally by the activity of two enzymes, cystathionine γ lyase (CSE) and cystathionine β synthetase (CBS). β-cyano-L-Alanine (BCA) is a reversible inhibitor of the H₂S-synthesizing enzyme CSE. BCA blocks H₂S synthesis in rat liver preparations with an IC₅₀ value of 6.5 μM and increases blood pressure in anaesthetized rats induced with hemorrhagic shock by inhibiting endogenous H₂S synthesis. BCA at 50 mg/kg blocked both L-cysteine- and LPS-induced hyperalgesia in rats.

β-L-cyanoalanine is an amino acid that promotes seed germination in A. albus seeds. Beta-Cyano-L-alanine in the diet of adult locusts causes a decrease in the hemolymph volume thereby affecting water balance responses. L-β-cyanoalanine is an inhibitor of vitamin B6.

Safety

• WGK Germany: 3
• Storage Class: 11 - Combustible Solids