powder , 136632-32-1

CAS NO.：136632-32-1

Empirical Formula: C19H35N3O4S1

Molecular Weight: 401.56

MDL number: MFCD00065506

EINECS: 603-969-3

PRODUCT Properties

• storage temp.: −20°C
• solubility: Soluble in ethanol at 20mg/ml
• form: powder
• color: white
• BRN: 7693643
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

Description and Uses

ALLM (136632-32-1) is a cell-permeable, peptide aldehyde inhibitor of calpain (calpain I, Ki= 120 nM, calpain II, Ki= 230 nM) and other neutral cysteine proteases. Potent inhibitor of cathepsin L (Ki=0.6 nM) and cathepsin B (Ki=100 nM).1Weak inhibitor of the chymotrypsin-like activity of the proteasome.2Cell permeable.

ALLM (Calpain Inhibitor) is a cell-permeable, peptide aldehyde inhibitor of calpain I and calpain II. ALLM acts as a very potent inhibitor of cathepsin L and the strongest inhibitor of cathepsin B amongst the peptide aldehydes. This compound inhibits the processing of malaria aspartic hemoglobinases plasmepsins I and IIin vitro. ALLM also inhibits other neutral cysteine proteases, and activation-induced programmed cell death. It restores defective immune responses in HIV+ donors. ALLM blocks nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. ALLM also acts as a weak inhibitor of proteasome.

Safety

• Safety Statements: 22-24/25
• WGK Germany: 3
• F: 3-10